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The role of MLL1 has been underexplored during decidualization. In our research, we found the expression of MLL1 was closely related to endometrial receptivity, and it was responsible to hormone stimulation. Inhibiting the function of MLL1 by MM102 reduced the transformation of HESCs. Furthermore, down\u2010regulation of MLL1 by siRNA transfection significantly decreased PGR and its target genes expression. MLL1 act as a co\u2010activator of ER\u03b1, and both of them were recruited to PGR regulatory regions, thus promote PGR transcription. Our study showed that MLL1 plays a key role in promoting progesterone signalling transmission.<\/jats:p>","DOI":"10.1111\/jcmm.16030","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T15:58:38Z","timestamp":1605628718000},"page":"297-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mixed\u2010lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7081-0805","authenticated-orcid":false,"given":"Yao","family":"Xiong","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center Zhongnan Hospital of Wuhan University  Wuhan China"},{"name":"Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health  Wuhan 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