{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:31:06Z","timestamp":1781015466447,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672469"],"award-info":[{"award-number":["81672469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702323"],"award-info":[{"award-number":["81702323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pancreatic cancer (PC) is a leading cause of cancer\u2010related mortality globally. Though increasing evidence has demonstrated that circular RNAs (circRNAs) are linked to the development and progression of cancers, the biological functions of circRNAs in PC remain largely unexplored so far. Based on previous studies, Hsc_circ_0075829 (circ_0075829) was screened out and then further identified in PC clinical specimens and cell lines by real\u2010time PCR. After the stability tests, a series of in vitro and in vivo functional experiments were performed to investigate the role of circ_0075829 in PC development. Furthermore, fluorescent in situ hybridization (FISH), bioinformatics tools, dual\u2010luciferase assays and rescue experiments were conducted to clarify the regulatory mechanisms of circ_0075829 in SW1990 and BxPC\u20103 cells. Compared with paracancerous tissues, the expression of circ_0075829 was increased in PC tissues, which was positively correlated with the clinical features of PC. Knockdown of circ_0075829 significantly suppressed the proliferative, migratory and invasive rates of SW1990 and BxPC\u20103 cells both in vitro and in vivo. Bioinformatics analysis and dual\u2010luciferase reporter gene assay indicated that circ_0075829 could bind to miR\u20101287\u20105p. Mechanism research and rescue experiments demonstrated that circ_0075829 could regulate the LAMTOR3\/p\u2010ERK signalling pathway via sponging miR\u20101287\u20105p in PC cell lines. Our data reveal that the circ_0075829 could facilitate the proliferation and metastasis of PC through circ_0075829\/miR\u20101287\u20105p\/LAMTOR3 axis.<\/jats:p>","DOI":"10.1111\/jcmm.16089","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T08:52:09Z","timestamp":1605257529000},"page":"14596-14607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Circ_0075829 facilitates the progression of pancreatic carcinoma by sponging miR\u20101287\u20105p and activating LAMTOR3 signalling"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-9413","authenticated-orcid":false,"given":"Xudong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China"},{"name":"Nanjing Medical University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailin","family":"Xue","sequence":"additional","affiliation":[{"name":"Nanjing Medical University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Cui","sequence":"additional","affiliation":[{"name":"Nanjing Medical University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China"},{"name":"Nanjing Medical University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yin","sequence":"additional","affiliation":[{"name":"Nanjing Medical University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-1679","authenticated-orcid":false,"given":"Xihu","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China"},{"name":"Nanjing Medical University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.66"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102655"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.4.765"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20344"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.09.026"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/280339a0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.361"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1671856"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12720"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1436-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0663-2"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7630894"},{"key":"e_1_2_10_15_1","first-page":"2923","article-title":"Circular RNA expression in pancreatic ductal adenocarcinoma","volume":"18","author":"Zhang Q","year":"2019","journal-title":"Oncology letters"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2015.1128065"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27190"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17121987"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.01.012"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S201310"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12629"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.42174"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-3268"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.02.021"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-175"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-019-1104-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108743"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.11.032"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63911-9"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0703-y"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-10-18"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2014.11.008"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23960"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2019.1649585"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11928"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0158-7"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1975"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.11.020"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.16089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T09:33:16Z","timestamp":1723109596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.16089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":37,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/jcmm.16089"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.16089","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]},"assertion":[{"value":"2020-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}