{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T16:37:38Z","timestamp":1783787858537,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370308"],"award-info":[{"award-number":["81370308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypoxia\/reoxygenation (H\/R)\u2010induced myocardial cell injury is the main cause of acute myocardial infarction (AMI). Many proofs show that circular RNA plays an important role in the development of AMI. The purpose of this study was to investigate the role of circSAMD4A in H\/R\u2010induced myocardial injury. The levels of circular SAMD4A (circSAMD4A) were detected in the heart tissues of AMI mice and H\/R\u2010induced H9C2 cells, and the circSAMD4A was suppressed in AMI mice and H\/R\u2010induced H9C2 cells to investigate its\u2019 function in AMI. The levels of circSAMD4A and miR\u2010138\u20105p were detected by real\u2010time quantitative PCR, and MTT assay was used to detect cell viability. TUNEL analysis and Annexin V\u2010FITC were used to determine apoptosis. The expression of Bcl\u20102 and Bax proteins was detected by Western blot. IL\u20101\u03b2, TNF\u2010\u03b1 and IL\u20106 were detected by ELISA kits. The study found that the levels of circSAMD4A were up\u2010regulated after H\/R induction and inhibition of circSAMD4A expression would reduce the H\/R\u2010induced apoptosis and inflammation. MiR\u2010138\u20105p was down\u2010regulated in H\/R\u2010induced H9C2 cells. circSAMD4A was a targeted regulator of miR\u2010138\u20105p. CircSAMD4A inhibited the expression of miR\u2010138\u20105p to promote H\/R\u2010induced myocardial cell injury in vitro and vivo. In conclusion, CircSAMD4A can sponge miR\u2010138\u20105p to promote H\/R\u2010induced apoptosis and inflammatory response.<\/jats:p>","DOI":"10.1111\/jcmm.16093","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T11:14:54Z","timestamp":1605957294000},"page":"1776-1784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["CircSAMD4A aggravates H\/R\u2010induced cardiomyocyte apoptosis and inflammatory response by sponging miR\u2010138\u20105p"],"prefix":"10.1111","volume":"26","author":[{"given":"Xiaorong","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiology Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruisong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tongren Hospital of Wuhan University Wuhan 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