{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:54:38Z","timestamp":1781304878113,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>H19<\/jats:italic> polymorphisms are associated with increased susceptibility to several cancers; however, their role in hepatoblastoma remains unclear. In this study, we investigated the association between three <jats:italic>H19<\/jats:italic> polymorphisms (rs2839698 G&gt;A, rs3024270 C&gt;G, rs217727 G&gt;A) and hepatoblastoma susceptibility in 213 hepatoblastoma patients. The rs2839698 and rs3024270 polymorphisms were associated with significantly increased hepatoblastoma risk, with the GG genotype associated with a higher risk of hepatoblastoma than the CC genotype at the rs3024270 locus. The rs217727 polymorphism was associated with significantly decreased hepatoblastoma risk, with the AG genotype associated with a lower risk of hepatoblastoma than the GG genotype. These findings were confirmed by combined analysis, and stratification analysis revealed that age, gender and clinical stage were associated with increased hepatoblastoma susceptibility. The GGG and AGG haplotypes were significantly associated with increased hepatoblastoma risk compared with the GCA reference (rs2839698, rs3024270, rs217727). The rs2839698 and rs3024270 polymorphisms correlated with decreased MRPL23\u2010AS1 expression, whereas the rs217727 polymorphism was associated with increased MRPL23\u2010AS1 expression. Overall, the <jats:italic>H19<\/jats:italic> rs2839698, rs3024270 and rs217727 polymorphisms were associated with hepatoblastoma susceptibility in a Chinese Han population.<\/jats:p>","DOI":"10.1111\/jcmm.16124","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T06:56:01Z","timestamp":1606287361000},"page":"742-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association between lncRNA\u2010<i>H19<\/i> polymorphisms and hepatoblastoma risk in an ethic Chinese population"],"prefix":"10.1111","volume":"25","author":[{"given":"Tianbao","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Women and Children\u2019s Medical Center Guangzhou Medical University  Guangzhou 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