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Cisplatin (CP) and aminoglycosides are effective antineoplastic or bactericidal drugs, and their application has a high probability of ototoxicity which results from the death of hair cells (HCs). Here, we describe the therapeutic effect of the flavonoid compound naringin (Nar) against ototoxic effects of cisplatin and aminoglycosides include gentamicin (GM) and neomycin (Neo) in zebrafish HCs. Animals incubated with Nar (100\u2010400\u00a0\u03bcmol\/L) were protected against the pernicious effects of CP (150\u2010250\u00a0\u03bcmol\/L), GM (50\u2010150\u00a0\u03bcmol\/L) and Neo (50\u2010150\u00a0\u03bcmol\/L). We also provide evidence for the potential mechanism of Nar against ototoxicity, including antioxidation, anti\u2010apoptosis, promoting proliferation and hair cell regeneration. We found that mRNA levels of the apoptotic\u2010 and pyroptosis\u2010related genes are regulated by Nar both in vivo and in vitro. Finally, by proving that Nar does not affect the anti\u2010tumour efficacy of CP and antibacterial activity of aminoglycosides in vitro, we highlight its value in clinical application. In conclusion, these results unravel a novel therapeutic role for Nar as an otoprotective drug against the adverse effects of CP and aminoglycosides.<\/jats:p>","DOI":"10.1111\/jcmm.16158","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T07:51:31Z","timestamp":1607068291000},"page":"975-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Naringin attenuates cisplatin\u2010 and aminoglycoside\u2010induced hair cell injury in the zebrafish lateral line via multiple pathways"],"prefix":"10.1111","volume":"25","author":[{"given":"Ming","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan China"},{"name":"Department of Orthopaedics Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan 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