{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:11Z","timestamp":1787015471922,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NV19\u201001\u201000435"],"award-info":[{"award-number":["NV19\u201001\u201000435"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In somatotroph pituitary tumours, somatostatin analogue (SSA) therapy outcomes vary throughout the studies. We performed an analysis of cohort of patients with acromegaly from the Czech registry to identify new prognostic and predictive factors. Clinical data of patients were collected, and complex immunohistochemical assessment of tumour samples was performed (SSTR1\u20105, dopamine D2 receptor, E\u2010cadherin, AIP). The study included 110 patients. In 31, SSA treatment outcome was evaluated. Sparsely granulated tumours (SGST) differed from the other subtypes in expression of SSTR2A, SSTR3, SSTR5 and E\u2010cadherin and occurred more often in young. No other clinical differences were observed. Trouillas grading system showed association with age, tumour size and SSTR2A expression. Factors significantly associated with SSA treatment outcome included age, IGF1 levels, tumour size and expression of E\u2010cadherin and SSTR2A. In the group of SGST, poor SSA response was observed in younger patients with larger tumours, lower levels of SSTR2A and higher Ki67. We observed no relationship with expression of other proteins including AIP. No predictive value of E\u2010cadherin was observed when tumour subtype was considered\n                    <jats:bold>.<\/jats:bold>\n                    Multiple additional factors apart from SSTR2A expression can predict treatment outcome in patients with acromegaly.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.16173","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T23:57:07Z","timestamp":1611532627000},"page":"2484-2492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Predictive and prognostic significance of tumour subtype, SSTR1\u20105 and e\u2010cadherin expression in a well\u2010defined cohort of patients with acromegaly"],"prefix":"10.1111","volume":"25","author":[{"given":"Jiri","family":"Soukup","sequence":"first","affiliation":[{"name":"The Fingerland Department of Pathology Faculty of Medicine University Hospital Charles University Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Hornychova","sequence":"additional","affiliation":[{"name":"The Fingerland Department of Pathology Faculty of Medicine University Hospital Charles University Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Manethova","sequence":"additional","affiliation":[{"name":"The Fingerland Department of Pathology Faculty of Medicine University Hospital Charles University Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kvetoslava","family":"Michalova","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Charles University Plzen Czech Republic"},{"name":"Bioptical Laboratory, Ltd. 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