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Due to the lack of effective early diagnosis and treatment methods, the molecular mechanism of myocardial remodelling should be explored in depth. In this study, we observed the high expression of MBNL1 in cardiac tissue and peripheral blood of an isoproterenol (ISO)\u2010induced cardiac hypertrophy mouse model. MBNL1 promoted ISO\u2010induced cardiac hypertrophy and fibrosis by stabilizing Myocardin mRNA in vivo and in vitro. Meanwhile, an increase in MBNL1 may induce the apoptosis of cardiomyocytes treated with ISO via TNF\u2010\u03b1 signalling. Interestingly, MBNL1 can be activated by p300 in cardiomyocytes treated with ISO. At last, Myocardin can reverse activate the expression of MBNL1. These results suggest that MBNL1 may be a potential target for the early diagnosis and clinical treatment of myocardial remodelling.<\/jats:p>","DOI":"10.1111\/jcmm.16177","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T04:56:01Z","timestamp":1607576161000},"page":"1100-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["MBNL1 regulates isoproterenol\u2010induced myocardial remodelling in vitro and in vivo"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-7303","authenticated-orcid":false,"given":"Yao","family":"Xu","sequence":"first","affiliation":[{"name":"College of Life Sciences and Health Wuhan University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Health Wuhan 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