{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:36:56Z","timestamp":1791999416250,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The peritoneum, especially the omentum, is a common site for gastric cancer (GC) metastasis. Our aim was to expound the role and mechanisms of Piezo1 on GC omentum metastasis. A series of functional assays were performed to examine cell proliferation, clone formation, apoptosis, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx, mitochondrial membrane potential (MMP) and migration after overexpression or knockdown of Piezo1. A GC peritoneal implantation and metastasis model was conducted. After infection by si\u2010Piezo1, the number and growth of tumours were observed in abdominal cavity. Fibre and angiogenesis were tested in metastatic tumour tissues. Piezo1 had higher expression in GC tissues with omentum metastasis and metastatic lymph node tissues than in GC tissues among 110 patients. High Piezo1 expression was associated with lymph metastasis, TNM and distant metastasis. Overexpressed Piezo1 facilitated cell proliferation and suppressed cell apoptosis in GC cells. Moreover, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx was elevated after up\u2010regulation of Piezo1. Piezo1 promoted cell migration and Calpain1\/2 expression via up\u2010regulation of HIF\u20101\u03b1 in GC cells. In vivo, Piezo1 knockdown significantly inhibited peritoneal metastasis of GC cells and blocked EMT process and angiogenesis. Our findings suggested that Piezo1 is a key component during GC omentum metastasis, which could be related to up\u2010regulation of HIF\u20101\u03b1.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.16217","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T09:38:27Z","timestamp":1610703507000},"page":"2238-2253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis"],"prefix":"10.1111","volume":"25","author":[{"given":"Xiaofei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology North China University of Science and Technology Affiliated Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Central Laboratory of Clinical Medical College North China 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