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More than 20 million people have already been infected by the virus. ACE2 is not only a functional receptor of COVID\u201019 but also an important endogenous antagonist of the renin\u2010angiotensin system (RAS). A large number of studies have shown that ACE2 can reverse myocardial injury in various cardiovascular diseases (CVDs) as well as is exert anti\u2010inflammatory, antioxidant, anti\u2010apoptotic and anticardiomyocyte fibrosis effects by regulating transforming growth factor beta, mitogen\u2010activated protein kinases, calcium ions in cells and other major pathways. The ACE2\/angiotensin\u2010(1\u20107)\/Mas receptor axis plays a decisive role in the cardiovascular system to combat the negative effects of the ACE\/angiotensin II\/angiotensin II type 1 receptor axis. However, the underlying mechanism of ACE2 in cardiac protection remains unclear. Some approaches for enhancing ACE2 expression in CVDs have been suggested, which may provide targets for the development of novel clinical therapies. 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