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It has always been a major problem in clinical treatment, mainly because its pathogenesis has not been well understood. The roles of bacterial contamination and prolonged wound inflammation were considered significant. IL\u201010 is a potent anti\u2010inflammatory cytokine and plays a pivotal role in wound healing and scar formation. Here, we investigate whether IL\u201010 alleviates lipopolysaccharide (LPS)\u2010induced inflammatory response and skin scarring and explore the possible mechanism of scar formation. Our results showed that the expression of TLR4 and pp65 was higher in HS and HS\u2010derived fibroblasts (HSFs) than their counterpart normal skin (NS) and NS\u2010derived fibroblasts (NSFs). LPS could up\u2010regulate the expression of TLR4, pp65, Col I, Col III and \u03b1\u2010SMA in NSFs, but IL\u201010 could down\u2010regulate their expression in both HSFs and LPS\u2010induced NSFs. Blocking IL\u201010 receptor (IL\u201010R) or the phosphorylation of STAT3, their expression was up\u2010regulated. In addition, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> models results showed that IL\u201010 could alleviate LPS\u2010induced fibroblast\u2010populated collagen lattice (FPCL) contraction and scar formation. Therefore, IL\u201010 alleviates LPS\u2010induced skin scarring via IL\u201010R\/STAT3 axis regulating TLR4\/NF\u2010\u03baB pathway in dermal fibroblasts by reducing ECM proteins deposition and the conversion of fibroblasts to myofibroblasts. Our results indicate that IL\u201010 can alleviate the LPS\u2010induced harmful effect on wound healing, reduce scar contracture, scar formation and skin fibrosis. Therefore, the down\u2010regulation of inflammation may lead to a suitable scar outcome and be a better option for improving scar quality.<\/jats:p>","DOI":"10.1111\/jcmm.16250","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T20:03:50Z","timestamp":1610309030000},"page":"1554-1567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["IL\u201010 alleviates lipopolysaccharide\u2010induced skin scarring via IL\u201010R\/STAT3 axis regulating TLR4\/NF\u2010\u03baB pathway in dermal fibroblasts"],"prefix":"10.1111","volume":"25","author":[{"given":"Jihong","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous 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