{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:54:54Z","timestamp":1788393294782,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672342"],"award-info":[{"award-number":["81672342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772527"],"award-info":[{"award-number":["81772527"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302072"],"award-info":[{"award-number":["81302072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2019QNA7028"],"award-info":[{"award-number":["2019QNA7028"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2019FZJD009"],"award-info":[{"award-number":["2019FZJD009"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Integrins, as a large family of cell adhesion molecules, play a crucial role in maintaining intestinal homeostasis. In inflammatory bowel disease (IBD), homeostasis is disrupted. Integrin \u03b1v\u03b26, which is mainly regulated by the integrin \u03b26 subunit gene (ITGB6), is a cell adhesion molecule that mediates cell\u2010cell and cell\u2010matrix interactions. However, the role of ITGB6 in the pathogenesis of IBD remains elusive. In this study, we found that ITGB6 was markedly upregulated in inflamed intestinal tissues from patients with IBD. Then, we generated an intestinal epithelial cell\u2010specific ITGB6 transgenic mouse model. Conditional ITGB6 transgene expression exacerbated experimental colitis in mouse models of acute and chronic dextran sulphate sodium (DSS)\u2010induced colitis. Survival analyses revealed that ITGB6 transgene expression correlated with poor prognosis in DSS\u2010induced colitis. Furthermore, our data indicated that ITGB6 transgene expression increased macrophages infiltration, pro\u2010inflammatory cytokines secretion, integrin ligands expression and Stat1 signalling pathway activation. Collectively, our findings revealed a previously unknown role of ITGB6 in IBD and highlighted the possibility of ITGB6 as a diagnostic marker and therapeutic target for IBD.<\/jats:p>","DOI":"10.1111\/jcmm.16297","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T04:56:53Z","timestamp":1611550613000},"page":"2679-2690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium\u2010induced colitis in mice"],"prefix":"10.1111","volume":"25","author":[{"given":"Haiyan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Department of Radiation Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Pathophysiology, and Department of Colorectal Surgery of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Center for Inflammatory Bowel Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Inflammatory Bowel Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Department of Pathology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Center for Inflammatory Bowel Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Center for Inflammatory Bowel Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiting","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Center for Inflammatory Bowel Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Cancer Institute Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Inflammatory Bowel Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefeng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Center for Inflammatory Bowel Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7164-0764","authenticated-orcid":false,"given":"Jingjing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Pathophysiology, and Department of Colorectal Surgery of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery and Oncology Key Laboratory of Cancer Prevention and Intervention Ministry of Education The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Center for Inflammatory Bowel Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0415-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317977"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.025"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4817"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000955"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.136"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35099066"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0223-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.038"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2017.1316573"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0038-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E15-06-0369"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2018.04.013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.06.025"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91372-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.01.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10208"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.06.009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310847"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy060"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.10.046"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.60"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90305-A"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.024"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.10"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311079"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60661-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0050-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9090116"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10258"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.017"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.2.214"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111453"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03097.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/13894501113149990006"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20148"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.7.995"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21175"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000236"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1652267"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3661"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02733"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00123.2016"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.89"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.026"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101387"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.65"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040965"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000368"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.16297","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T11:50:23Z","timestamp":1714391423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.16297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,24]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/jcmm.16297"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.16297","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,24]]},"assertion":[{"value":"2020-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}