{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:09:13Z","timestamp":1776913753830,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long\u2010term poorly controlled myocardial hypertrophy often leads to heart failure and sudden death. Activation of ras\u2010related C3 botulinum toxin substrate 1 (RAC1) by angiotensin II (Ang II) plays a pivotal role in myocardial hypertrophy. Previous studies have demonstrated that scoparone (SCO) has beneficial effects on hypertension and extracellular matrix remodelling. However, the function of SCO on Ang II\u2010mediated myocardial hypertrophy remains unknown. In our study, a mouse model of myocardial hypertrophy was established by Ang II infusion (2\u00a0mg\/kg\/day) for 4\u00a0weeks, and SCO (60\u00a0mg\/kg bodyweight) was administered by gavage\u00a0daily. In vitro experiments were also performed. Our results showed that SCO could alleviate Ang II infusion\u2010induced cardiac hypertrophy and fibrosis in mice. In vitro, SCO treatment blocks Ang II\u2010induced cardiomyocyte hypertrophy, cardiac fibroblast collagen synthesis and differentiation to myofibroblasts. Meanwhile, we found that SCO treatment blocked Ang II\u2010induced oxidative stress in cardiomyocytes and cardiac fibroblasts by inhibiting RAC1\u2010GTP and total RAC1 in vivo and in vitro. Furthermore, reactive oxygen species (ROS) burst by overexpression of RAC1 completely abolished SCO\u2010mediated protection in cardiomyocytes and cardiac fibroblasts in vitro. In conclusion, SCO, an antioxidant, may attenuate Ang II\u2010induced myocardial hypertrophy by suppressing of RAC1 mediated oxidative stress.<\/jats:p>","DOI":"10.1111\/jcmm.16304","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T22:49:11Z","timestamp":1612997351000},"page":"3136-3148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Scoparone alleviates Ang II\u2010induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress"],"prefix":"10.1111","volume":"25","author":[{"given":"Linmao","family":"Lyu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Qilu Hospital of Shandong University Jinan China"},{"name":"Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University Jinan 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Qilu Hospital of Shandong University Jinan China"},{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences: The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine; Qilu Hospital of Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Qilu Hospital of Shandong University Jinan China"},{"name":"Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University Jinan China"},{"name":"Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary\u2010Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University Jinan China"},{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences: The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine; Qilu Hospital of Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-5090","authenticated-orcid":false,"given":"Lijun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Shandong Academy of Occupational Health and Occupational Medicine Shandong 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