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In recent years, accumulating evidence found that exosomal miRNAs participate in many diseases of reproductive system. However, the specific role of miRNAs, particularly the follicular fluid\u2010derived exosomal miRNAs in OHSS remains controversial. To identify differentially expressed follicular fluid exosomal miRNAs from OHSS and non\u2010OHSS patients, the analysis based on miRNA\u2010sequence was conducted. The levels of 291 miRNAs were significantly differed in exosomes from OHSS patients compared with normal control, and exosomal miR\u201027 was one of the most significantly down\u2010regulated miRNAs in the OHSS group. By using MiR\u201027 mimic, we found it could increase ROS stress and apoptosis by down\u2010regulating the expression of p\u2010ERK\/Nrf2 pathway by negatively regulating SPRY2. These data demonstrate that exosomal miRNAs are differentially expressed in follicular fluid between patients with and without OHSS, and follicular fluid exosomal miR\u201027 may involve in the pathological process of OHSS development.<\/jats:p>","DOI":"10.1111\/jcmm.16355","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T11:42:44Z","timestamp":1614426164000},"page":"3976-3990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exosomal miR\u201027 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS"],"prefix":"10.1111","volume":"25","author":[{"given":"Kailu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 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