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This review surveyed the single nucleotide polymorphisms (SNPs), copy number variations (CNVs), hypermethylation, regulation mechanism, correlation with clinicopathological parameters and chemotherapeutic resistance of DKK4. The signal pathways involved in DKK4 mainly include Wnt\/\u03b2\u2010catenin pathway and Wnt\u2010JNK pathway independent \u03b2\u2010catenin. DKK4 expression was upregulated in Renal Cell Carcinoma (RCC), Colorectal Cancer, Gastric Cancer (GC), Non\u2010small Cell Lung Cancer (NSCLC) and Epithelial Ovarian Cancer (EOC), while downregulated in Hepatocellular Carcinoma (HCC). DKK4 is not only involved in tumour growth, invasion, migration and chemotherapy resistance, but also in osteoblastogenesis and secondary hair or meibomian gland formation. DKK4 has also been linked to schizophrenia.<\/jats:p>","DOI":"10.1111\/jcmm.16372","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T03:19:41Z","timestamp":1613359181000},"page":"2786-2794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A literature review on function and regulation mechanism of DKK4"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-0651","authenticated-orcid":false,"given":"Xiaoli","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Central Laboratory Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine 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