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They could be used to transport molecules with a poor bioavailability such as curcumin in order to improve their clinical usage. This natural polyphenol, well\u2010known for its antioxidant and anti\u2010inflammatory properties, has a poor solubility that limits its clinical potential. For this purpose, the use of NDS27, a curcumin salt complexed with hydroxypropyl\u2010beta\u2010cyclodextrin (HP\u03b2CD), displaying an increased solubility in aqueous solution, is preferred. This study aims to evaluate the uptake of NDS27 into skeletal muscle\u2010derived mesenchymal stem cells (mdMSCs) and the effects of such uptake onto their mesenchymal properties. It appeared that the uptake of NDS27 into mdMSCs is concentration\u2010dependent and not time\u2010dependent. The use of a concentration of 7\u00a0\u00b5mol\/L which does not affect the viability and proliferation also allows preservation of their adhesion, invasion and T cell immunomodulatory abilities.<\/jats:p>","DOI":"10.1111\/jcmm.16403","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T11:44:28Z","timestamp":1616759068000},"page":"4877-4881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell\u2010based therapy development"],"prefix":"10.1111","volume":"25","author":[{"given":"Margaux","family":"Colin","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Pharmaceuticals Faculty of Pharmacy Universit\u00e9 libre de Bruxelles (ULB) Brussels Belgium"},{"name":"RD3\u2010 Pharmacognosy, Bioanalysis and Drug Discovery Unit and Analytical 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