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Persistent colonization of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    leading to chronic infection is responsible for gastritis and malignancy. Autophagy is an evolutionary conserved process which can protect cells and organisms from bacterial infection. Here, we demonstrated that\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection induced autophagosome formation but inhibited autophagic flux. SIRT1, a class III histone deacetylase, was down\u2010regulated at both mRNA and protein levels by\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection in gastric cells. Further investigation showed that the transcriptional factor RUNX3 accounted for down\u2010regulation of SIRT1 in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2010infected gastric cells. SIRT1 promoted autophagic flux in gastric cells and activation of SIRT1 restored the autophagic flux inhibited by\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection. Furthermore, SIRT1 exerted inhibitory effects on intracellular survival and colonization of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . And activation of autophagic flux in SIRT1\u2010inhibited gastric cells could significantly reduce intracellular load of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . Moreover, the relationship between\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection and SIRT1 expression was identified in clinical specimen. Our findings define the importance of SIRT1 in compromised autophagy induced by\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection and bacterial intracellular colonization. These results provide evidence that SIRT1 can serve as a therapeutic target to eradicate\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.16411","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T08:50:00Z","timestamp":1614502200000},"page":"3348-3360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<i>Helicobacter<\/i>\n                    <i>pylori<\/i>\n                    inhibits autophagic flux and promotes its intracellular survival and colonization by down\u2010regulating SIRT1"],"prefix":"10.1111","volume":"25","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Pathogen Biology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traditional Medicine Qilu Hospital Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathology Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"An","sequence":"additional","affiliation":[{"name":"Institute of Pathogen Biology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Pathogen Biology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Jia","sequence":"additional","affiliation":[{"name":"Institute of Pathogen Biology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Key Laboratory for Experimental Teratology of Ministry of Education Shandong University  Jinan China"},{"name":"Shandong Key Laboratory of Infection and Immunity Shandong University  Jinan China"},{"name":"Karolinska Institute Collaborative Laboratory for Cancer research Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4385-1521","authenticated-orcid":false,"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Pathogen Biology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Key Laboratory for Experimental Teratology of Ministry of Education Shandong University  Jinan China"},{"name":"Shandong Key Laboratory of Infection and Immunity Shandong University  Jinan China"},{"name":"Karolinska Institute Collaborative Laboratory for Cancer research Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0886-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00222.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.049"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.20159"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407657102"},{"key":"e_1_2_9_7_1","first-page":"S1536","article-title":"Gastric carcinogenesis in rhesus monkeys. 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