{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:01:53Z","timestamp":1781326913380,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800499"],"award-info":[{"award-number":["81800499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["2017117"],"award-info":[{"award-number":["2017117"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MicroRNA\u2010122 (miR\u2010122) is known to be up\u2010regulated by inflammation to exert a variety of biological functions in hepatocellular carcinoma (HCC)\u2010derived human cell lines. Vitamin D receptor (VDR) is reported to regulate excessive oral keratinocytes apoptosis which compromises oral epithelial barrier in oral lichen planus (OLP). Although many studies have suggested that miR\u2010122 is capable of regulating cell apoptosis, its effects on the development of OLP and VDR expression are still unclear. Herein, we demonstrate that miR\u2010122 expression is increased in the epithelial layer of OLP. Mechanically, transcription factor nuclear factor\u2010\u03baB (NF\u2010\u03baB) selectively binds with \u03baB element in the promoter of <jats:italic>miR\u2010122<\/jats:italic> to accelerate gene transcription. The up\u2010regulation of miR\u2010122 induces cell apoptosis in human oral keratinocytes (HOKs) by targeting VDR mRNA. In <jats:italic>VDR<\/jats:italic> knockout oral keratinocytes, miR\u2010122 fails to improve caspase 3 activity and cleaved caspase 3 and poly(ADP\u2010ribose) polymerase (PARP) levels. Moreover, VDR overexpression is able to reverse lipopolysaccharide (LPS)\u2010 or activated CD4+ T cell\u2013induced miR\u2010122 up\u2010regulation and ameliorate miR\u2010122\u2010stimulated caspase 3 activity. Collectively, our results suggest that miR\u2010122 promotes oral keratinocytes apoptosis in OLP through decreasing VDR expression.<\/jats:p>","DOI":"10.1111\/jcmm.16418","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T12:13:19Z","timestamp":1614773599000},"page":"3400-3407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["MicroRNA\u2010122 promotes apoptosis of keratinocytes in oral lichen planus through suppressing VDR expression"],"prefix":"10.1111","volume":"25","author":[{"given":"Xuejun","family":"Ge","sequence":"first","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology Taiyuan China"},{"name":"Department of Endodontics Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanting","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanxi Medical University Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology Taiyuan China"},{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanxi Medical University Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-2497","authenticated-orcid":false,"given":"Jie","family":"Du","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology Taiyuan China"},{"name":"Department of Oral Medicine Shanxi Medical University School and Hospital of Stomatology Taiyuan China"},{"name":"Institute of Biomedical Research Shanxi Medical University Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01142.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12885"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.05.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12339"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1667-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.18827"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04303"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.07.154"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.211"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22806"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.05.013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.09.022"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23818"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.12.023"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23875"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1781009"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63539"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076867"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02575-07"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.3.325"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12659"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19234-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0331-9"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801020RRR"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-1002-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22998"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173374"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.110690"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402008000300001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2533"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.18.9831"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2207-8"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.07.031"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.467670"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12634"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813371106"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.161"},{"key":"e_1_2_9_39_1","first-page":"1373","article-title":"miR122 and miR199 synergistically promote autophagy in oral lichen planus by targeting the Akt\/mTOR pathway","volume":"43","author":"Wang L","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26525-y"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.16418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T08:19:41Z","timestamp":1692605981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.16418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/jcmm.16418"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.16418","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]},"assertion":[{"value":"2020-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}