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However, the biological processes and clinical significance of most lncRNAs in hepatoblastoma (HB) remain unclear. In our previous study, genome\u2010wide analysis with a lncRNA microarray found that lncRNA HOXA\u2010AS2 was up\u2010regulated in HB. Stable transfected cell lines with HOXA\u2010AS2 knockdown or overexpression were constructed in HepG2 and Huh6 cells, respectively. Our data revealed knockdown of HOXA\u2010AS2 increased cell apoptosis and inhibited cell proliferation, migration and invasion in HB. Up\u2010regulation of HOXA\u2010AS2 promoted HB malignant biological behaviours. Mechanistic investigations indicated that HOXA\u2010AS2 was modulated by chromatin remodelling factor ARID1B and transcription co\u2010activator SUB1, thereby protecting HOXA3 from degradation. Therefore, HOXA\u2010AS2 positively regulates HOXA3, which might partly demonstrate the involvement of HOXA3 in HOXA\u2010AS2\u2010mediated HB carcinogenesis. In conclusion, HOXA\u2010AS2 is significantly overexpressed in HB and the ARID1B\/HOXA\u2010AS2\/HOXA3 axis plays a critical role in HB tumorigenesis and development. These results might provide a potential new target for HB diagnosis and therapy.<\/jats:p>","DOI":"10.1111\/jcmm.16435","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T16:28:32Z","timestamp":1615220912000},"page":"3524-3536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["ARID1B\/SUB1\u2010activated lncRNA HOXA\u2010AS2 drives the malignant behaviour of hepatoblastoma through regulation of HOXA3"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7788-1879","authenticated-orcid":false,"given":"Gongbao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Children\u2019s Hospital of Fudan University Shanghai China"},{"name":"Key Laboratory of Neonatal Disease Ministry of Health Shanghai 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