{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:26:19Z","timestamp":1770906379651,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Growing lncRNAs have been noted to involve in the initiation and development of several tumours including tongue squamous cell carcinomas (TSCCs). However, the biological role and mechanism of lncRNA RPSAP52 were not well\u2010explained. We indicated that RPSAP52 was higher in TSCC samples compared with that in control samples. The higher expression of RPSAP52 was positively correlated with higher T stage and TNM stage. Ectopic expression of RPSAP52 induced TSCC cell growth and cycle and induced cytokine secretion including IFN\u2010\u03b3, IL\u20101\u03b2 and IL\u20106, IL\u20108, IL\u201010 and TGF\u2010\u03b2. We found that the overexpression of RPSAP52 suppressed miR\u2010423\u20105p expression in SCC\u20104 cell. miR\u2010423\u20105p was lower in TSCC samples compared with that in control samples, and miR\u2010423\u20105p level was negatively correlated with higher T stage and TNM stage. Pearson's correlation indicated that miR\u2010423\u20105p was negatively associated with that of RPSAP52 in TSCC tissues. Furthermore, MYBL2 was one direct gene of miR\u2010423\u20105p and elevated expression of miR\u2010423\u20105p suppressed MYBL2 expression and ectopic expression of RPSAP52 increased MYBL2 expression in SCC\u20104 cell. Finally, we illustrated that RPSAP52 overexpression promoted TSCC cell growth and cycle and induced cytokine secretion including IFN\u2010\u03b3, IL\u20101\u03b2 and IL\u20106, IL\u20108, IL\u201010 and TGF\u2010\u03b2 via modulating MYBL2. These data provided new insight into RPSAP52, which may be one potential treatment target for TSCC.<\/jats:p>","DOI":"10.1111\/jcmm.16442","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T02:29:50Z","timestamp":1617157790000},"page":"4744-4752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["lncRNA RPSAP52 induced the development of tongue squamous cell carcinomas via miR\u2010423\u20105p\/MYBL2"],"prefix":"10.1111","volume":"25","author":[{"given":"Xiaozhen","family":"Wu","sequence":"first","affiliation":[{"name":"Department of stomatology Aerospace Center Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0672-3563","authenticated-orcid":false,"given":"Zuode","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endodontics Jinan Stomatological Hospital Jinan 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