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However, the therapy is still challenging because the immunomodulatory properties of BMSCs are always impaired by immunopathogenesis in patients. Because of its reliable and extensive biological activities, osthole has received increased clinical attention. In this study, we found that BMSCs derived from osteoporosis donors were ineffective in cell therapy for experimental inflammatory colitis and osteoporosis. In vivo and in vitro tests showed that because of the down\u2010regulation of Fas and FasL expression, the ability of osteoporotic BMSCs to induce T\u2010cell apoptosis decreased. Through the application of osthole, we successfully restored the immunosuppressive ability of osteoporotic BMSCs and improved their treatment efficacy in experimental inflammatory colitis and osteoporosis. In addition, we found the immunomodulatory properties of BMSCs were enhanced after osthole pre\u2010treatment. In this study, our data highlight a new approach of pharmacological modification (ie osthole) to improve the immune regulatory performance of BMSCs from a healthy or inflammatory microenvironment. The development of targeted strategies to enhance immunosuppressive therapy using BMSCs may be significantly improved by these findings.<\/jats:p>","DOI":"10.1111\/jcmm.16459","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T02:24:06Z","timestamp":1616379846000},"page":"4835-4845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Osthole enhances the immunosuppressive effects of bone marrow\u2010derived mesenchymal stem cells by promoting the Fas\/FasL system"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8646-8963","authenticated-orcid":false,"given":"Yang","family":"Yu","sequence":"first","affiliation":[{"name":"Northern Department of Endodontics Stomatological Hospital of Chongqing Medical University Chongqing China"},{"name":"Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing China"},{"name":"Chongqing Municipal 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