{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:55:46Z","timestamp":1789826146735,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01DK08506505A1"],"award-info":[{"award-number":["2R01DK08506505A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nintedanib, an Food and Drug Administration (FDA) approved multiple tyrosine kinase inhibitor, exhibits an anti\u2010fibrotic effect in lung and kidneys. Its effect on peritoneal fibrosis remains unexplored. In this study, we found that nintedanib administration lessened chlorhexidine gluconate (CG)\u2010induced peritoneal fibrosis and reduced collagen I and fibronectin expression. This coincided with suppressed phosphorylation of platelet\u2010derived growth factor receptor, fibroblast growth factor receptors, vascular endothelial growth factor receptor and Src family kinase. Mechanistically, nintedanib inhibited injury\u2010induced mesothelial\u2010to\u2010mesenchymal transition (MMT), as demonstrated by decreased expression of \u03b1\u2010smooth muscle antigen and vimentin and preserved expression of E\u2010cadherin in the CG\u2010injured peritoneum and cultured human peritoneal mesothelial cells exposed to transforming growth factor\u2010\u03b21. Nintedanib also suppressed expression of Snail and Twist, two transcription factors associated with MMT in vivo and in vitro. Moreover, nintedanib treatment inhibited expression of several cytokines\/chemokines, including tumour necrosis factor\u2010\u03b1, interleukin\u20101\u03b2 and interleukin\u20106, monocyte chemoattractant protein\u20101 and prevented infiltration of macrophages to the injured peritoneum. Finally, nintedanib reduced CG\u2010induced peritoneal vascularization. These data suggest that nintedanib may attenuate peritoneal fibrosis by inhibiting MMT, inflammation, and angiogenesis and have therapeutic potential for the prevention and treatment of peritoneal fibrosis in patients on peritoneal dialysis.<\/jats:p>","DOI":"10.1111\/jcmm.16518","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T10:10:50Z","timestamp":1620209450000},"page":"6103-6114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Nintedanib attenuates peritoneal fibrosis by inhibiting mesothelial\u2010to\u2010mesenchymal transition, inflammation and angiogenesis"],"prefix":"10.1111","volume":"25","author":[{"given":"Feng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology Shanghai East Hospital Tongji University School of Medicine Shanghai 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