{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:05:40Z","timestamp":1788930340521,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002808","name":"Carlsbergfondet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carbon monoxide (CO) is the leading cause of death by poisoning worldwide. The aim was to explore the effects of mild and severe poisoning on blood gas parameters and metabolites. Eleven pigs were exposed to CO intoxication and had blood collected before and during poisoning. Mild CO poisoning (carboxyhaemoglobin, COHb 35.2\u00a0\u00b1\u00a07.9%) was achieved at 32\u00a0\u00b1\u00a013\u00a0minutes, and severe poisoning (69.3\u00a0\u00b1\u00a010.2% COHb) at 64\u00a0\u00b1\u00a023\u00a0minutes from baseline (2.9\u00a0\u00b1\u00a00.5% COHb). Blood gas parameters and metabolites were measured on a blood gas analyser and nuclear magnetic resonance spectrometer, respectively. Unsupervised principal component, analysis of variance and Pearson's correlation tests were applied. A <jats:italic>P<\/jats:italic>\u2010value \u2264\u00a0.05 was considered statistically significant. Mild poisoning resulted in a 28.4% drop in oxyhaemoglobin (OHb) and 12\u2010fold increase in COHb, while severe poisoning in a 65% drop in OHb and 24\u2010fold increase in COHb. Among others, metabolites implicated in regulation of metabolic acidosis (lactate, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), energy balance (pyruvate, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001; 3\u2010hydroxybutyrc acid, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), respiration (citrate, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007; succinate, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0003; fumarate, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), lipid metabolism (glycerol, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002; choline, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0002) and antioxidant\u2010oxidant balance (glutathione, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03; hypoxanthine, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) were altered, especially during severe poisoning. Our study adds new insights into the deranged metabolism of CO poisoning and leads the way for further investigation.<\/jats:p>","DOI":"10.1111\/jcmm.16522","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T09:23:43Z","timestamp":1620206623000},"page":"5191-5201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Metabolic changes during carbon monoxide poisoning: An experimental study"],"prefix":"10.1111","volume":"25","author":[{"given":"Carsten","family":"Simonsen","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigri\u00f0ur Olga","family":"Magnusdottir","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Biomedical Research Laboratory Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Jesper","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Wimmer","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Bioscience Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil Steen","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Anaesthesiology and Intensive Care Pulmonary Research Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedict","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Biomedical Research Laboratory Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2332-2312","authenticated-orcid":false,"given":"Raluca Georgiana","family":"Maltesen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Pulmonary Research Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563659409017973"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.02.006"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"163","article-title":"Carbon monoxide poisoning: a new incidence for an old disease","volume":"34","author":"Hampson NB","year":"2007","journal-title":"Undersea Hyperb Med"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210767"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2004.05.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2007.10.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.12130"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2007.12.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650903468209"},{"key":"e_1_2_10_11_1","article-title":"Hyperbaric oxygen for carbon monoxide poisoning","volume":"4","author":"Buckley NA","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201606-1275CI"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201204-0688OC"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800304105"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.059063"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.206706"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2015.05.004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2015.1124110"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-012-0875-2"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7110462"},{"key":"e_1_2_10_21_1","unstructured":"MaltesenRG.Postoperative lung injury\u2010 the path from initiation to clinical diagnosis: a molecular view on a complex pathophysiological process.Aalborg University Press. 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