{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:33:58Z","timestamp":1772606038458,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumour radioresistance is a major problem for cancer radiation therapy. To identify the underlying mechanisms of this resistance, we used human non\u2010small cell lung cancer (NSCLC) cell lines and focused on the Inhibitor of Apoptosis Protein (IAP) family, which contributes to tumourigenesis and chemoresistance. We investigated the possible correlation between radioresistance in six NSCLC cell lines and IAP protein levels and tested the radiosensitizing effect of birinapant in vitro, a molecule that mimics the second mitochondria\u2010derived activator of caspase. We found that birinapant\u2010induced apoptosis and inhibited the proliferation of NSCLC cells after exposure to radiation. These effects were induced by birinapant downregulation of cIAP protein levels and changes of cIAP gene expression. Overall, birinapant can inhibit tumour growth of NSCLC cell lines to ironizing radiation and act as a promising strategy to overcome radioresistance in NSCLC.<\/jats:p>","DOI":"10.1111\/jcmm.16526","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T15:34:38Z","timestamp":1620056078000},"page":"6125-6136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["cIAP1\/2 are involved in the radiosensitizing effect of birinapant on NSCLC cell line in vitro"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8270-6183","authenticated-orcid":false,"given":"Hao","family":"Sun","sequence":"first","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Du","sequence":"additional","affiliation":[{"name":"Tianjin Center for Disease Control and Prevention Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaihua","family":"Ji","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqing","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manman","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1653-4122","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaixue","family":"Wen","sequence":"additional","affiliation":[{"name":"Shanxi Academy of Medical Sciences Shanxi Bethune Hospital Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-6868","authenticated-orcid":false,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30123-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.5064"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140134"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(84)90545-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1982.300"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098231"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.05.017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-015-2709-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2889"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509313103"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3627"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400795"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/40901"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.8.2215"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.14.7787"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.16.7003-7014.2004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg083"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1621"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.11.5959"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/35050012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/379349a0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.07.045"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1789"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15829"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0541-0"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2018-0324"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.6.1415"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318226b4a6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0188"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3317"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.47"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2004.08.004"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9041012"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.037"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.030"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.08.029"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.042"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0218"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0507-4"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8246"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01225918"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor066"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2376"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190319114641"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091105"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.226258"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.16526","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T11:18:01Z","timestamp":1693394281000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.16526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":47,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/jcmm.16526"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.16526","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"2020-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}