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Inflammation is a central pathophysiological feature of the heart in response to both acute and chronic injury, while the molecular basis and underlying mechanisms remains obscure. Interleukin (IL)\u201013, a pro\u2010inflammatory cytokine, has been known as a critical mediator in allergy and asthma. Recent studies appraise the role of IL\u201013 in CVDs, revealing that IL\u201013 is not only involved in more obvious cardiac inflammatory diseases such as myocarditis but also relevant to acute or chronic CVDs of other origins, such as myocardial infarction and heart failure. The goal of this review is to summarize the advancement in our knowledge of the regulations and functions of IL\u201013 in CVDs and to discuss the possible mechanisms of IL\u201013 involved in CVDs. We highlight that IL\u201013 may be a promising target for immunotherapy in CVDs.<\/jats:p>","DOI":"10.1111\/jcmm.16566","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T12:27:36Z","timestamp":1620131256000},"page":"5351-5357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Emerging role of interleukin\u201013 in cardiovascular diseases: A ray of hope"],"prefix":"10.1111","volume":"25","author":[{"given":"Ningjing","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Cardiovascular Key Lab of Zhejiang Province Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital Zhejiang University School of Medicine 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