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The outbreak of the 2019 novel coronavirus\u2010disease COVID\u201019 represented a pandemic threat and declared a public health emergency of international concern. Herein, the role of glycans for the development of new drugs or vaccines, as a host\u2010targeted approach, is discussed where may provide a front\u2010line prophylactic or threats to protect against the current and any future respiratory\u2010infecting virus and possibly against other respiratory pathogens. As a prototype, the role of glycans in the coronavirus infection, as well as, galectins (Gal) as the glycan\u2010recognition agents (GRAs) in drug design are here summarized. Galectins, in particular, Gal\u20101 and Gal\u20103 are ubiquitous and important to biological systems, whose interactions with viral glycans modulate host immunity and homeostatic balance.<\/jats:p>","DOI":"10.1111\/jcmm.16585","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T11:57:57Z","timestamp":1621857477000},"page":"5842-5856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Targeting the glycans: A paradigm for host\u2010targeted and COVID\u201019 drug design"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1724-5392","authenticated-orcid":false,"given":"Fatemeh","family":"Pourrajab","sequence":"first","affiliation":[{"name":"Reproductive Immunology Research Center Shahid Sadoughi University of Medical Sciences Yazd Iran"},{"name":"Nutrition and Food Security Research Center Shahid Sadoughi University of Medical Sciences Yazd Iran"},{"name":"Biotechnology Research Center, International Campus Shahid Sadoughi University of Medical Sciences Yazd 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