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We initially identified that 386 mRNAs, 144 miRNAs and 2548 circRNAs were differentially expressed (DE) in RIF and then investigated the genetic cause of the observed abnormal expression by constructing a circRNA\u2010miRNA\u2010mRNA network considering the competing endogenous RNA theory. We further analysed the upstream transcription factors and related kinases of DEmRNAs (DEMs) and demonstrated that SUZ12, AR, TP63, NANOG, and TCF3 were the top five TFs binding to these DEMs. Besides, protein\u2010protein interaction analysis disclosed that ACTB, CXCL10, PTGS2, CXCL12, GNG4, AGT, CXCL11, SST, PENK, and FOXM1 were the top 10 hub genes in the acquired network. Finally, we performed the functional enrichment analysis and found that arrhythmogenic right ventricular cardiomyopathy (ARVC), hypertrophic cardiomyopathy (HCM), pathways in cancer, TNF signalling pathway and steroid hormone biosynthesis were the potentially disrupted pathways in RIF patients. Optimistically, our findings may deepen our apprehensions about the underlying molecular and biological causes of RIF and provide vital clues for future laboratory and clinical experiments that will ultimately bring a better outcome for patients with RIF.<\/jats:p>","DOI":"10.1111\/jcmm.16586","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T18:41:45Z","timestamp":1620499305000},"page":"1853-1864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Construction of circRNA\u2010miRNA\u2010mRNA network in the pathogenesis of recurrent implantation failure using integrated bioinformatics study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4751-4212","authenticated-orcid":false,"given":"Mohsen","family":"Ahmadi","sequence":"first","affiliation":[{"name":"Student Research Committee Hormozgan University of Medical Sciences  Bandar Abbas 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