{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:43:24Z","timestamp":1774453404332,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Single nucleotide polymorphism (SNP) array and karyotype analyses were conducted on 441 spontaneous miscarriage placental villous tissues collected from women from southern China. Subsequently, the results from these two analyses were compared to evaluate the best diagnostic strategy for subsequent pre\u2010pregnancy planning. Here, the success rate of genetic testing using karyotyping and SNP array analysis was 78.46% (346\/441) and 100.0% (441\/441), respectively. The abnormality rate estimated by both methods was 54.9% (242\/441). Three hundred and forty\u2010six cases were successfully detected via both SNP array and karyotype analyses; the rate of consistent detection was 96.24% (333\/346), whereas 13 cases were not consistent. There was no substantial positive correlation between age and genetic abnormalities such as Turner syndrome, structural variation or euploidy state in the different age groups studied. However, the aneuploidy rate was significantly different in each age group. Thus, although SNP array has higher success rate and resolution in genetic abnormality detection, supplementary karyotype analysis is needed for a more accurate revelation of the genetic aetiology of miscarriages. Therefore, this study indicates that simultaneous karyotype and SNP array analyses should be performed for spontaneous miscarriages. Furthermore, miscarriages irrespective of maternal age must be genetically analysed.<\/jats:p>","DOI":"10.1111\/jcmm.16588","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T07:06:27Z","timestamp":1620716787000},"page":"5721-5728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative clinical genetic testing in spontaneous miscarriage: Insights from a study in Southern Chinese women"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7431-2475","authenticated-orcid":false,"given":"Meiying","family":"Cai","sequence":"first","affiliation":[{"name":"Department of the Prenatal Diagnosis Center Fujian Maternity and Child Health Hospital Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of the Prenatal Diagnosis Center Fujian Maternity and Child Health Hospital Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangpu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of the Prenatal Diagnosis Center Fujian Maternity and Child Health Hospital Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-399X","authenticated-orcid":false,"given":"Hailong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of the Prenatal Diagnosis Center Fujian Maternity and Child Health Hospital Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69204-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.07.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00034"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210449"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-017-0297-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00308-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365973"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2013.74.1.36"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.07.001"},{"key":"e_1_2_9_11_1","first-page":"127","article-title":"Genetic and epidemiologic investigation of spontaneous abortion: relevance to clinical practice","volume":"15","author":"Warburton D","year":"1979","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5200\/sm-hs.2016.059"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477707"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-1069-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2933"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181f8baad"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.12.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.01.022"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2010.0014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13039-015-0210-z"},{"issue":"74","key":"e_1_2_9_21_1","first-page":"36","article-title":"Evaluation of array comparative genomic hybridization in recurrent miscarriage","volume":"2013","author":"Mcnamee K","year":"2005","journal-title":"Br J Hosp Med (Lond)"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03418.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12926"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444064"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16080"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.174"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000160075.96707.04"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8166-7-38"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.147494"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2014.57.6.518"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33083"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/302878"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203382"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2015.03.010"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.10.011"},{"key":"e_1_2_9_36_1","first-page":"127","article-title":"Genetic and epidemiologic investigation of spontaneous abortion: relevance to clinical practice","volume":"44","author":"Warburton D","year":"1979","journal-title":"Birth Defects Original Article"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.446"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048087"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des251"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2012.750696"},{"key":"e_1_2_9_41_1","first-page":"575","article-title":"Analysis of fetal chromosomal karyotype and etiology in 252 cases of early spontaneous abortion","volume":"28","author":"Zhang HK","year":"2011","journal-title":"Chin J Med Genet"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.16588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T07:03:46Z","timestamp":1693379026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.16588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,10]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/jcmm.16588"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.16588","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,10]]},"assertion":[{"value":"2021-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}