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The purpose of this study is to demonstrate whether Chalocomoracin (CMR), a novel purified compound from fungus\u2010infected mulberry leaves, is able to inhibit vitreous\u2010induced signalling events and cellular responses intrinsic to PVR. Our studies have revealed that the CMR IC50 for ARPE\u201019 cells is 35.5\u00a0\u03bcmol\/L at 72\u00a0hours, and that 5\u00a0\u03bcmol\/L CMR inhibits vitreous\u2010induced Akt activation and p53 suppression; in addition, we have discovered that this chemical effectively blocks vitreous\u2010stimulated proliferation, migration and contraction of ARPE\u201019 cells, suggesting that CMR is a promising PVR prophylactic.<\/jats:p>","DOI":"10.1111\/jcmm.16590","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T15:45:47Z","timestamp":1629906347000},"page":"9102-9111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chalcomoracin prevents vitreous\u2010induced activation of AKT and migration of retinal pigment epithelial 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