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However, the pathological mechanisms leading to traumatic HO remain unknown. Here, we report that aberrant expression of IL\u201017 promotes traumatic HO formation by activating \u03b2\u2010catenin signalling in mouse model. We found that elevated IL\u201017 and \u03b2\u2010catenin levels are correlated with a high degree of HO formation in specimens from patients and HO animals. We also show that IL\u201017 initiates and promotes HO progression in mice. Local injection of an IL\u201017 neutralizing antibody attenuates ectopic bone formation in a traumatic mouse model. IL\u201017 enhances the osteoblastic differentiation of mesenchymal stem cells (MSCs) by activating \u03b2\u2010catenin signalling. Moreover, inhibition of IL\u201017R or \u03b2\u2010catenin signalling by neutralizing antibodies or drugs prevents the osteogenic differentiation of isolated MSCs and decreases HO formation in mouse models. Together, our study identifies a novel role for active IL\u201017 as the inducer and promoter of ectopic bone formation and suggests that IL\u201017 inhibition might be a potential therapeutic target in traumatic HO.<\/jats:p>","DOI":"10.1111\/jcmm.16617","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T03:09:34Z","timestamp":1625108974000},"page":"7709-7719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inhibition of IL\u201017 prevents the progression of traumatic heterotopic ossification"],"prefix":"10.1111","volume":"25","author":[{"given":"Bing","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Jiaotong University Affiliated Sixth People\u2019s Hospital  Shanghai China"},{"name":"Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai 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