{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:23:24Z","timestamp":1747185804764,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial ischemia\u2010reperfusion injury (MIRI) with concurrent severe sepsis has led to substantial mortality. Mild hypothermia (MHT) has been proved to have a therapeutic effect in either MIRI or severe sepsis, which suggests it might be beneficial for MIRI complicating severe sepsis. In this study, Sprague\u2010Dawley rats with MIRI complicating severe sepsis were allotted in either MHT (33\u00a0\u00b1\u00a00.5\u00b0C) group or normothermia (NT, 37\u00a0\u00b1\u00a00.5\u00b0C) group; as control, rats receiving sham surgery and normal saline were kept at NT. After 2h of temperature maintenance, blood and heart tissue were acquired for detections. Lactate dehydrogenase (LDH) and MB isoenzyme of creatine kinase (CK\u2010MB) in blood, triphenyl tetrazolium chloride and Evans blue staining, hematoxylin and eosin staining for myocardium were employed to detect myocardial damage. Tumor necrosis factor (TNF)\u2010\u03b1 and caspase\u20103 was performed by immunohistochemistry to exam myocardial inflammation and apoptosis. Detection of NADPH oxidase (NOX) 2 was for myocardial oxidative stress. In MHT group, systolic blood pressure was improved significantly compared with NT group. Myocardial infarct size, morphological change, LDH and CK\u2010MB levels were attenuated compared to NT group. Moreover, less expressions of TNF\u2010\u03b1, caspase\u20103 and NOX2 in MHT group were presented compared with NT group. MHT showed cardioprotection by improving cardiac dysfunction, reducing myocardial infarct size and attenuating myocardial injury, inflammation, apoptosis and oxidative stress.<\/jats:p>","DOI":"10.1111\/jcmm.16649","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T09:19:41Z","timestamp":1622452781000},"page":"6448-6454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mild hypothermia in rat with acute myocardial ischaemia\u2010reperfusion injury complicating severe sepsis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-1083","authenticated-orcid":false,"given":"Zhuyun","family":"Qin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital Beijing 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