{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:49:49Z","timestamp":1784771389286,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphangiogenesis is possibly capable of attenuating hypertension\u2010induced cardiac injury. Sirtuin 3 (SIRT3) is an effective mitochondrial deacetylase that has the potential to modulate this process; however, its role in hypertension\u2010induced cardiac lymphangiogenesis to date has not been investigated. Our experiments were performed on 8\u2010week\u2010old wild\u2010type (WT), SIRT3 knockout (SIRT3\u2010KO) and SIRT3 overexpression (SIRT3\u2010LV) mice infused with angiotensin II (Ang II) (1000\u00a0ng\/kg per minute) or saline for 28\u00a0days. After Ang II infusion, SIRT3\u2010KO mice developed a more severe cardiac remodelling, less lymphatic capillaries and lower expression of lymphatic marker when compared to wild\u2010type mice. In comparison, SIRT3\u2010LV restored lymphangiogenesis and attenuated cardiac injury. Furthermore, lymphatic endothelial cells (LECs) exposed to Ang II in vitro exhibited decreased migration and proliferation. Silencing SIRT3 induced functional decrease in LECs, while SIRT3 overexpression LECs facilitated. Moreover, SIRT3 may up\u2010regulate lymphangiogenesis by affecting vascular endothelial growth factor receptor 3 (VEGFR3) and ERK pathway. These findings suggest that SIRT3 could promote lymphangiogenesis and attenuate hypertensive cardiac injury.<\/jats:p>","DOI":"10.1111\/jcmm.16661","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T01:25:30Z","timestamp":1624843530000},"page":"7760-7771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sirtuin 3 deficiency aggravates angiotensin II\u2010induced hypertensive cardiac injury by the impairment of lymphangiogenesis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-7512","authenticated-orcid":false,"given":"Chen","family":"Zhang","sequence":"first","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese National Health Commission and Chinese Academy of Medical Sciences The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular 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