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Here, we report that pseudolaric acid B (PAB) attenuated articular cartilage degeneration and synovitis during OA. PAB, a diterpene acid, specifically inhibited NF\u2010\u03baB signalling and reduced the production of pro\u2010inflammatory cytokines, which further decreased M1 polarization and vessel formation. We further provide in vivo and in vitro evidences that PAB suppressed NF\u2010\u03baB signalling by stabilizing PPAR\u03b3. Using PPAR\u03b3 antagonist could abolish anti\u2010inflammatory effect of PAB and rescue the activation of NF\u2010\u03baB signalling during OA. Our findings identify a previously unrecognized role of PAB in the regulation of OA and provide mechanisms by which PAB regulates NF\u2010\u03baB signalling through PPAR\u03b3, which further suggest targeting synovial inflammation or inhibiting vessel formation at early stage could be an effective preventive strategy for OA.<\/jats:p>","DOI":"10.1111\/jcmm.16670","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T01:22:37Z","timestamp":1623460957000},"page":"6664-6678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPAR\u03b3 to inhibit NF\u2010\u03baB signalling pathway"],"prefix":"10.1111","volume":"25","author":[{"given":"Jiansen","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Southern Medical University Guangzhou 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