{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:06Z","timestamp":1787015466547,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970317"],"award-info":[{"award-number":["81970317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970411"],"award-info":[{"award-number":["81970411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogen sulphide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) inhibits vascular smooth muscle cell (VSMC) proliferation induced by hyperglycaemia and hyperlipidaemia; however, the mechanisms are unclear. Here, we observed lower H\n                    <jats:sub>2<\/jats:sub>\n                    S levels and higher expression of the proliferation\u2010related proteins PCNA and cyclin D1 in db\/db mouse aortae and vascular smooth muscle cells treated with 40\u00a0mmol\/L glucose and 500\u00a0\u03bcmol\/L palmitate, whereas exogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S decreased PCNA and cyclin D1 expression. The nuclear translocation of mitochondrial pyruvate dehydrogenase complex\u2010E1 (PDC\u2010E1) was significantly increased in VSMCs treated with high glucose and palmitate, and it increased the level of acetyl\u2010CoA and histone acetylation (H3K9Ac). Exogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S inhibited PDC\u2010E1 translocation from the mitochondria to the nucleus because PDC\u2010E1 was modified by S\u2010sulfhydration. In addition, PDC\u2010E1 was mutated at Cys101. Overexpression of PDC\u2010E1 mutated at Cys101 increased histone acetylation (H3K9Ac) and VSMC proliferation. Based on these findings, H\n                    <jats:sub>2<\/jats:sub>\n                    S regulated PDC\u2010E1 S\u2010sulfhydration at Cys101 to prevent its translocation from the mitochondria to the nucleus and to inhibit VSMC proliferation under diabetic conditions.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.16688","type":"journal-article","created":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T15:48:45Z","timestamp":1629560925000},"page":"8201-8214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exogenous H\n                    <sub>2<\/sub>\n                    S prevents the nuclear translocation of PDC\u2010E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state"],"prefix":"10.1111","volume":"25","author":[{"given":"Linxue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Functional experiment center Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-5260","authenticated-orcid":false,"given":"Weihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022314"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19368"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0550-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.046"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.050"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-017-1616-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13825"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3391"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-016-0099-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2AN36113B"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14774"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1525-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000373973"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.018"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00564-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.12.5.2186-2192.1992"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00397.2005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2017.07.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700021-MCP200"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118648"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07006-0"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.10.015"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.02.003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.08.007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00205"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014050"}],"container-title":["Journal 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