{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:11:05Z","timestamp":1788876665843,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770765"],"award-info":[{"award-number":["81770765"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873872"],"award-info":[{"award-number":["81873872"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071781"],"award-info":[{"award-number":["82071781"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peritoneal membrane dysfunction and the resulting ultrafiltration failure are the major disadvantages of long\u2010term peritoneal dialysis (PD). It becomes increasingly clear that mesothelial cells play a vital role in the pathophysiological changes of the peritoneal membrane. Matrix metalloproteinases (MMPs) function in the extracellular environment of cells and mediate extracellular matrix turnover during peritoneal membrane homeostasis. We showed here that dialysate MMP\u20107 levels markedly increased in the patients with PD, and the elevated MMP\u20107 level was negatively associated with peritoneal ultrafiltration volume. Interestingly, MMP\u20107 could regulate the cell osmotic pressure and volume of human peritoneal mesothelial cells. Moreover, we provided the evidence that MMP\u20107 activated mitogen\u2010activated protein kinases (MAPKs)\u2010extracellular signal\u2010regulated kinase 1\/2 (ERK) pathway and subsequently promoted the expression of aquaporin\u20101 (AQP\u20101) resulting in the change of cell osmotic pressure. Using a specific inhibitor of ERK pathway abrogated the MMP\u20107\u2010mediating AQP\u20101 up\u2010regulation and cellular homeostasis. In summary, all the findings indicate that MMP\u20107 could modulate the activity of peritoneal cavity during PD, and dialysate MMP\u20107 might be a non\u2010invasive biomarker and an alternative therapeutic target for PD patients with ultrafiltration failure.<\/jats:p>","DOI":"10.1111\/jcmm.16697","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T01:39:03Z","timestamp":1623461943000},"page":"6887-6898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["MMP\u20107 affects peritoneal ultrafiltration associated with elevated aquaporin\u20101 expression via MAPK\/ERK pathway in peritoneal mesothelial cells"],"prefix":"10.1111","volume":"25","author":[{"given":"Yue","family":"Yin","sequence":"first","affiliation":[{"name":"Division of Nephrology State Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Guangdong Provincial Key Laboratory of Renal Failure Research Guangzhou Regenerative Medicine and Health Guangdong Laboratory Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Department of Medical Laboratory School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology State Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Guangdong Provincial Key Laboratory of Renal Failure Research Guangzhou Regenerative Medicine and Health Guangdong Laboratory Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Nephrology State Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Guangdong Provincial Key Laboratory of Renal Failure Research Guangzhou Regenerative Medicine and Health Guangdong Laboratory Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaomu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou China"},{"name":"Department of Immunology School of Basic Medical Sciences Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirong","family":"Gong","sequence":"additional","affiliation":[{"name":"Division of Nephrology State Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Guangdong Provincial Key Laboratory of Renal Failure Research Guangzhou Regenerative Medicine and Health Guangdong Laboratory Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-9474","authenticated-orcid":false,"given":"Daming","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou China"},{"name":"Microbiome Medicine Center Zhujiang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ai","sequence":"additional","affiliation":[{"name":"Division of Nephrology State Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Guangdong Provincial Key Laboratory of Renal Failure Research Guangzhou Regenerative Medicine and Health Guangdong Laboratory Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01815"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07480618"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00092"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00290"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.250"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000285"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012080869"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.v1251036"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00037.2012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.06.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/928315"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.11.043"},{"key":"e_1_2_9_15_1","first-page":"21","article-title":"Matrix metalloproteinases\u20107 and kidney fibrosis","volume":"8","author":"Ke B","year":"2017","journal-title":"Front Physiol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.118.020660"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477132"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3791\/2204"},{"issue":"4","key":"e_1_2_9_19_1","first-page":"530","article-title":"Influence of glucose solutions on the development of hyperglycaemia in peritoneal dialysis. Behaviour of glycated haemoglobin and the lipid profile","volume":"34","author":"Delgado\u2010Cordova M","year":"2014","journal-title":"Nefrologia"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201006\u2010230086"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2017.05.013"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10060960"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2016030354"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101755.1998.00181.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686089901900209"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29341"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctm.2018.08.001"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511093331906"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01144"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.21076"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02519"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06\u20101089"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmc\u20102016\u20100022"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13545"},{"issue":"1","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/ndt\/gfw076","article-title":"Matrix metalloproteinase 9 is associated with peritoneal membrane solute transport and induces angiogenesis through beta\u2010catenin signaling","volume":"32","author":"Padwal M","year":"2017","journal-title":"Nephrol Dial Transpl"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02875-8"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.can\u201005\u20104268"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12574"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.417451"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201008\u2010172742"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000136995.83451.1d"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m010021200"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107793.1998.481be.x"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.16697","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:51:55Z","timestamp":1788875515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.16697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,11]]},"references-count":42,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/jcmm.16697"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.16697","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,11]]},"assertion":[{"value":"2021-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}