{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:03:42Z","timestamp":1783577022390,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20190134"],"award-info":[{"award-number":["BK20190134"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Smoking and <jats:italic>Candida<\/jats:italic> <jats:italic>albicans<\/jats:italic> (<jats:italic>C<\/jats:italic>.\u00a0<jats:italic>albicans<\/jats:italic>) infection are risk factors for many oral diseases. Several studies have reported a close relationship between smoking and the occurrence of <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>albicans<\/jats:italic> infection. However, the exact underlying mechanism of this relationship remains unclear. We established a rat infection model and a <jats:italic>C.\u00a0albicans<\/jats:italic>\u2010Leuk1 epithelial cell co\u2010culture model with and without smoke exposure to investigate the mechanism by which smoking contributes to <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>albicans<\/jats:italic> infection. Oral mucosa samples from healthy individuals and patients with oral leucoplakia were also analysed according to their smoking status. Our results indicated that smoking induced oxidative stress and redox dysfunction in the oral mucosa. Smoking\u2010induced Nrf2 negatively regulated the NLRP3 inflammasome, impaired the oral mucosal defence response and increased the oral mucosa susceptibility to <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>albicans<\/jats:italic>. The results suggest that the Nrf2 pathway could be involved in the pathogenesis of oral diseases by mediating an antioxidative response to cigarette smoke exposure and suppressing host immunity against <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>albicans<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/jcmm.16724","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T04:42:47Z","timestamp":1624336967000},"page":"7948-7960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Smoking increases oral mucosa susceptibility to <i>Candida albicans<\/i> infection via the Nrf2 pathway: In vitro and animal studies"],"prefix":"10.1111","volume":"25","author":[{"given":"Pei","family":"Ye","sequence":"first","affiliation":[{"name":"Nanjing Stomatological Hospital &amp; State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing China"},{"name":"Jiangsu Key Laboratory of Molecular Medicine Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital &amp; State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Huang","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital &amp; State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital &amp; State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Nan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital &amp; State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital &amp; State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Dong","family":"Han","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital &amp; State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing China"},{"name":"Jiangsu Key Laboratory of Molecular Medicine Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital &amp; State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.10.023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01115.x"},{"key":"e_1_2_10_4_1","first-page":"9847","article-title":"Prevalence of oral Candida carriage and Candida species among cigarette and maras powder users","volume":"8","author":"Keten HS","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2016.1220018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.01.058"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28695"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246222"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2012.10.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13628"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11624"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0415-155RR"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/503363"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-14-61"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-009-9217-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00102.2012"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.033"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6700"},{"key":"e_1_2_10_20_1","first-page":"349","article-title":"Characterization of stage\u2010specific embryonic antigen\u20101 (SSEA\u20101) expression during early development of the turkey embryo","volume":"43","author":"D'Costa S","year":"1999","journal-title":"Int J Dev Biol"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00085-18"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90699"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.195172"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430112"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050252"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1095-6"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12120"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8441"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.03.010"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2017.12.012"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403104"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/foz081"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600043"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.01.043"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0321OC"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.033"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.05.002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00182-15"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.114"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.05.002"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7864150"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2725"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6615"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16724","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.16724","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T10:41:34Z","timestamp":1710931294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.16724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,21]]},"references-count":42,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/jcmm.16724"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.16724","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,21]]},"assertion":[{"value":"2020-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}