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The strict and accurate modulation of the mitochondrial quality control system, comprising the mitochondrial fission\/fusion, mitophagy and other processes, can ameliorate the myocardial injury of myocardial ischaemia and ischaemia\u2010reperfusion after myocardial infarction, which plays an important role in myocardial protection after myocardial infarction. Further research into the mechanism will help identify new therapeutic targets and drugs for the treatment of myocardial infarction. 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