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Numerous reports have demonstrated that alterations in the expression of microRNAs (miRNAs) are related to liver disease. However, the effect of individual miRNAs on liver fibrosis has not been studied. Hepatic stellate cells (HSCs), being responsible for producing ECM, exert an important influence on liver fibrosis. Then, microarray analysis of non\u2010activated and activated HSCs induced by transforming growth factor \u03b21 (TGF\u2010\u03b21) showed that miR\u2010130b\u20105p expression was strongly up\u2010regulated during HSC activation. Moreover, the progression of liver fibrosis had a close connection with the expression of miR\u2010130b\u20105p in different liver fibrosis mouse models. Then, we identified that there were specific binding sites between miR\u2010130b\u20105p and the 3\u2032 UTR of Sirtuin 4 (SIRT4) via a luciferase reporter assay. Knockdown of miR\u2010130b\u20105p increased SIRT4 expression and ameliorated liver fibrosis in mice transfected with antagomiR\u2010130b\u20105p oligos. In general, our results suggested that miR\u2010130b\u20105p promoted HSC activation by targeting SIRT4, which participates in the AMPK\/TGF\u2010\u03b2\/Smad2\/3 signalling pathway. Hence, regulating miR\u2010130b\u20105p maybe serve as a crucial therapeutic treatment for hepatic fibrosis.<\/jats:p>","DOI":"10.1111\/jcmm.16766","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T07:41:02Z","timestamp":1626507662000},"page":"7381-7394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["miRNA\u2010130b\u20105p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7252-2674","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"first","affiliation":[{"name":"Hepatobiliary\/Liver Transplantation Center The First Affiliated Hospital with Nanjing Medical University Nanjing China"},{"name":"Key Laboratory of Liver Transplantation Chinese Academy of Medical Sciences Nanjing China"},{"name":"Key Laboratory of 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