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Treatments for OA include non\u2010pharmacological interventions, topical and oral therapies, intra\u2010articular therapies and joint surgery. However, all the treatments mentioned above mainly aim to control the symptoms instead of improving or reversing the joint condition. In this research, we observed the effect of recombinant platelet\u2010derived growth factor (PDGF)\u2010BB on OA in a monosodium iodoacetate (MIA)\u2013induced rat model and revealed the possible mechanisms. In vitro, the level of inflammation in the chondrocytes was gradually alleviated, and the apoptosis rate was gradually decreased by PDGF\u2010BB at increasing concentrations. The levels of p\u2010p38, Bax and caspase\u20103 decreased, and the level of p\u2010Erk increased with increasing PDGF\u2010BB concentration. In vivo, PDGF\u2010BB could significantly reverse chondrocyte and matrix loss. Furthermore, high concentrations of PDGF\u2010BB could alleviate cartilage hyperplasia to remodel the tissue. The level of collagen II was up\u2010regulated, and the levels of collagen X and apoptosis were down\u2010regulated by increasing concentrations of PDGF\u2010BB. In conclusion, recombinant PDGF\u2010BB alleviated OA by down\u2010regulating caspase\u20103\u2010dependent apoptosis. The effects of PDGF\u2010BB on OA mainly include inhibiting chondrocyte loss, reducing cartilage hyperplasia and osteophyte formation, and regulating collagen anabolism.<\/jats:p>","DOI":"10.1111\/jcmm.16779","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T02:55:57Z","timestamp":1626058557000},"page":"7472-7484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Recombinant platelet\u2010derived growth factor\u2010BB alleviates osteoarthritis in a rat model by decreasing chondrocyte apoptosis in vitro and in vivo"],"prefix":"10.1111","volume":"25","author":[{"given":"Pengfei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Cardiology Wuhan Fourth Hospital Puai Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 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