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Nevertheless, little progress has been made in the signature of N<jats:sup>1<\/jats:sup>\u2010methyladenosine (m<jats:sup>1<\/jats:sup>A), 5\u2010methylcytosine (m<jats:sup>5<\/jats:sup>C), N<jats:sup>6<\/jats:sup>\u2010methyladenosine (m<jats:sup>6<\/jats:sup>A)\u2010related regulators and the tumour microenvironment (TME) cell infiltration in CM. Our study identified the characteristics of m<jats:sup>1<\/jats:sup>A\u2010, m<jats:sup>5<\/jats:sup>C\u2010 and m<jats:sup>6<\/jats:sup>A\u2010related regulators based on 468 CM samples from the public database. Using univariate, multivariate and LASSO Cox regression analysis, a risk model of regulators was established and validated by a nomogram on independent prognostic factors. The gene set variation analysis (GSVA) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) clarified the involved functional pathways. A combined single\u2010sample gene set enrichment analysis (ssGSEA) and CIBERSORT approach revealed TME of regulator\u2010related prognostic signature. The nine\u2010gene signature stratified the patients into distinct risk subgroups for personalized prognostic assessment. Additionally, functional enrichment, immune infiltration and immunotherapy response analysis indicated that the high\u2010risk group was correlated with T\u2010cell suppression, while the low\u2010risk group was more sensitive to immunotherapy. The findings presented here contribute to our understanding of the TME molecular heterogeneity in CM. Nine m<jats:sup>1<\/jats:sup>A\u2010, m<jats:sup>5<\/jats:sup>C\u2010 and m<jats:sup>6<\/jats:sup>A\u2010related regulators may also be promising biomarkers for future research.<\/jats:p>","DOI":"10.1111\/jcmm.16800","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T07:46:21Z","timestamp":1626853581000},"page":"8405-8418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prognostic signature and immune efficacy of m<sup>1<\/sup>A\u2010, m<sup>5<\/sup>C\u2010 and m<sup>6<\/sup>A\u2010related regulators in cutaneous melanoma"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4803-5934","authenticated-orcid":false,"given":"Xian rui","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery of Third Xiangya Hospital Central South University Changsha Hunan 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