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Growing evidence indicates that long non\u2010coding RNAs (lncRNAs) play an important role in aerobic glycolysis of various tumours. However, the correlation between lncRNAs and glycolysis in thyroid cancer cells is still poorly understood. In this study, we showed that lncRNA papillary thyroid cancer susceptibility candidate 3 (PTCSC3) was significantly downregulated in papillary thyroid carcinoma (PTC). Overexpression of PTCSC3 significantly inhibited the aerobic glycolysis and tumour growth of PTC cells. Consistently, PTCSC3 overexpression suppressed tumour progress in vivo. Mechanistically, PTCSC3 inhibits aerobic glycolysis and proliferation of PTC by directly interacting with PGK1, a key enzyme in glycolytic pathway. As a result, PTCSC3 performs its role in PTC development via PGK1 and may be a potential therapeutic target for PTC treatment.<\/jats:p>","DOI":"10.1111\/jcmm.16806","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T06:38:12Z","timestamp":1627886292000},"page":"8454-8463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["PTCSC3\u2010mediated glycolysis suppresses thyroid cancer progression via interfering with PGK1 degradation"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4967-6127","authenticated-orcid":false,"given":"Bo","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of General Surgery Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery Xiangya 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