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A total of 204 incident CAPD patients from four PD centres in Shanghai between 1 January 2014 and 30 September 2020 were grouped based on a peritoneal equilibration test after the first month of dialysis. Analysed with multivariate Cox and logistic regression models, baseline high PSTR was a significant risk factor for technique failure (AHR 5.70; 95% CI 1.581 to 20.548 <jats:italic>p\u00a0<\/jats:italic>=\u00a00.008). Baseline hyperuricemia was an independent predictor of mortality (AHR 1.006 95%CI 1.003 to 1.008, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) and baseline high PSTR (AOR 1.007; 95%CI 1.003 to 1.012; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.020). Since uric acid was closely related to high PSTR and adverse prognosis, the in vitro experiments were performed to explore the underlying mechanisms of which uric acid affected peritoneum. We found hyperuricemia induced epithelial\u2010to\u2010mesenchymal transition (EMT) of cultured human peritoneal mesothelial cells by activating TGF\u2010\u03b21\/Smad3 signalling pathway and nuclear transcription factors. Conclusively, high baseline PSTR induced by hyperuricaemia through EMT was an important reason of poor outcomes in CAPD patients.<\/jats:p>","DOI":"10.1111\/jcmm.16819","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T06:54:17Z","timestamp":1627282457000},"page":"8628-8644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The prognosis and risk factors of baseline high peritoneal transporters on patients with peritoneal dialysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Guansen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nephrology Shanghai East Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanghai East Hospital Tongji University School of Medicine Shanghai 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