{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T18:21:24Z","timestamp":1766600484827,"version":"3.44.0"},"reference-count":33,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770689","82070716"],"award-info":[{"award-number":["81770689","82070716"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Urethral stricture (US) is a common disorder of the lower urinary tract in men caused by fibrosis. The recurrence rate of US is high; however, there are no effective therapies to prevent or treat urethral fibrosis. The pathogenesis of urethral fibrosis involves myofibroblast activation and excessive extracellular matrix (ECM) deposition. The molecular mechanisms underlying this pathological activation are not completely understood. It has been demonstrated that Notch signalling contributes to the development of fibrosis and inflammation. However, whether this contributes to urethral fibrosis remains unclear. In this study, activation of Notch signalling was observed in patients with US. Additionally, it was noted that activation of Notch signalling promoted ECM production and myofibroblast activation in human urethral scar fibroblasts (HUSFs) treated with transforming growth factor (TGF) \u03b21. However, the Notch inhibitor <jats:italic>N<\/jats:italic>\u2010[<jats:italic>N<\/jats:italic>\u2010(3,5\u2010difluorophenacetyl)\u2010L\u2010alanyl]\u2010S\u2010phenylglycine t\u2010butyl ester (DAPT) suppressed activation of Notch signalling as well as proliferation and migration of the TGF\u03b21\u2010treated HUSFs. Additionally, DAPT ameliorated TGF\u03b21\u2010induced urethral fibrosis in Sprague Dawley rats by suppressing ECM production, myofibroblast activation and the TGF\u03b2 signalling pathway. These findings demonstrate that Notch signalling may be a promising and potential target in the prevention or treatment of urethral fibrosis.<\/jats:p>","DOI":"10.1111\/jcmm.16837","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T03:35:59Z","timestamp":1628307359000},"page":"8796-8808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of a gamma\u2010secretase inhibitor of notch signalling on transforming growth factor \u03b21\u2010induced urethral fibrosis"],"prefix":"10.1111","volume":"25","author":[{"given":"Shanlong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Urology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delai","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Urology The Second Affiliated Hospital of Xi'an Jiaotong 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