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In this study, naturally ageing mice were administered intragastrically with AST at 30\u00a0mg\/kg\/day (ageing\u00a0+\u00a0AST\u2010L group) and 90\u00a0mg\/kg\/day (ageing\u00a0+\u00a0AST\u2010H group) for 16\u201320\u00a0months. Adult (4\u00a0months old) and ageing mice were given 1% sodium carboxyl methylcellulose as vehicle. Energy metabolism\u2010related biological parameters of living mice were examined. Moreover, mRNA and protein levels of key enzymes\/proteins involved in triglyceride (TG) lipolysis, fatty acid \u03b2\u2010oxidation (FAO), ketone body (KB) production and mitochondrial respiratory chain were also examined after sacrifice. Results demonstrated that treatment with AST significantly reduced body weight, white fat and liver\/body weight ratio of ageing mice, significantly reduced serum\/hepatic TG levels, respiratory quotient, promoted fatty acid mobilization in white adipose tissue, mitochondrial FAO and KB production and mitochondrial biosynthesis\/functions in the liver of ageing mice. AST also up\u2010regulated the expression of phosphorylated AMP\u2010activated protein kinase, acetyl\u2010CoA carboxylase, acetyl\u2010coenzyme A synthetase, carnitine palmitoyltransferase 1a\/1b, enoyl coenzyme A hydratase\u2010short chain, acyl\u2010CoA dehydrogenase medium chain and mitochondrial 3\u2010hydroxy\u20103\u2010methylglutaryl\u2010CoA synthase\u20102 involved in fat metabolism. These results indicated that mitochondrial activity could be the target of AST to treat abnormal fat metabolism during ageing.<\/jats:p>","DOI":"10.1111\/jcmm.16847","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T04:44:29Z","timestamp":1629175469000},"page":"8863-8876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["RETRACTED: Astragaloside IV ameliorates fat metabolism in the liver of ageing mice through targeting mitochondrial activity"],"prefix":"10.1111","volume":"25","author":[{"given":"Zhixiao","family":"Luo","sequence":"first","affiliation":[{"name":"Health Management Center The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Medical Science China Three Gorges University Yichang 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