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In this study, we examined the effects of an immune\u2010modulating peptide, WKYMVm, that is an agonist for formyl peptide receptors (FPRs). Administration of WKYMVm into collagen\u2010induced arthritis (CIA) mice, an animal model for RA, attenuated paw thickness, clinical scores, production of type II collagen\u2010specific antibodies and inflammatory cytokines. WKYMVm treatment also decreased the numbers of T<jats:sub>H<\/jats:sub>1 and T<jats:sub>H<\/jats:sub>17 cells in the spleens of CIA mice. WKYMVm attenuated T<jats:sub>H<\/jats:sub>1 and T<jats:sub>H<\/jats:sub>17 differentiation in a dendritic cell (DC)\u2010dependent manner. WKYMVm\u2010induced beneficial effects against CIA and WKYMVm\u2010attenuated T<jats:sub>H<\/jats:sub>1 and T<jats:sub>H<\/jats:sub>17 differentiation were reversed by cyclosporin H but not by WRW4, indicating a crucial role of FPR1. We also found that WKYMVm augmented IL\u201010 production from lipopolysaccharide\u2010stimulated DCs and WKYMVm failed to suppress T<jats:sub>H<\/jats:sub>1 and T<jats:sub>H<\/jats:sub>17 differentiation in the presence of anti\u2010IL\u201010 antibody. The therapeutic administration of WKYMVm also elicited beneficial outcome against CIA. Collectively, we demonstrate that WKYMVm stimulation of FPR1 in DCs suppresses the generation of T<jats:sub>H<\/jats:sub>1 and T<jats:sub>H<\/jats:sub>17 cells via IL\u201010 production, providing novel insight into the function of FPR1 in regulating CIA pathogenesis.<\/jats:p>","DOI":"10.1111\/jcmm.16854","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T01:46:30Z","timestamp":1628646390000},"page":"8936-8946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Activation of formyl peptide receptor 1 elicits therapeutic effects against collagen\u2010induced arthritis"],"prefix":"10.1111","volume":"25","author":[{"given":"Byunghyun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Sungkyunkwan University Suwon 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