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However, effects of MSC\u2010derived exosomes on OA remain unclear. The study aimed to investigate the therapeutic potential of exosomes from human bone marrow MSCs (BM\u2010MSCs) in alleviating OA. The anterior cruciate ligament transection (ACLT) and destabilization of the medial meniscus (DMM) surgery were performed on the knee joints of a rat OA model, followed by intra\u2010articular injection of BM\u2010MSCs or their exosomes. In addition, BM\u2010MSC\u2010derived exosomes were administrated to primary human chondrocytes to observe the functional and molecular alterations. Both of BM\u2010MSCs and BM\u2010MSC\u2010derived exosomes alleviated cartilage destruction and subchondral bone remodelling in OA rat model. Administration of BM\u2010MSCs and exosomes could reduce joint damage and restore the trabecular bone volume fraction, trabecular number and connectivity density of OA rats. In addition, in vitro assays showed that BM\u2010MSCs\u2010exosomes could maintain the chondrocyte phenotype by increasing collagen type II synthesis and inhibiting IL\u20101\u03b2\u2013induced senescence and apoptosis. Furthermore, exosomal lncRNA MEG\u20103 also reduced the senescence and apoptosis of chondrocytes induced by IL\u20101\u03b2, indicating that lncRNA MEG\u20103\u00a0might partially account the anti\u2010OA effects of BM\u2010MSC exosomes. The exosomes from BM\u2010MSCs exerted beneficial therapeutic effects on OA by reducing the senescence and apoptosis of chondrocytes, suggesting that MSC\u2010derived exosomes might provide a candidate therapy for OA treatment.<\/jats:p>","DOI":"10.1111\/jcmm.16860","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T11:41:47Z","timestamp":1630064507000},"page":"9281-9294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":159,"title":["Therapeutic effects of bone marrow mesenchymal stem cells\u2010derived exosomes on osteoarthritis"],"prefix":"10.1111","volume":"25","author":[{"given":"Yi","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Rheumatology Affiliated Hospital of Nantong University Nantong China"},{"name":"Medical School Nantong University Nantong 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