{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:54:40Z","timestamp":1792504480445,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2016CM28"],"award-info":[{"award-number":["ZR2016CM28"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Retinal pigment epithelium (RPE) is a highly polarized epithelial monolayer lying between the photoreceptor layer and the Bruch membrane. It is essential for vision through participating in many critical activities, including phagocytosis\u00a0of photoreceptor outer segments, recycling the visual cycle\u2010related compounds,\u00a0forming a barrier to control the transport of nutrients, ions, and water, and the removal of waste. Primary cilia are conservatively present in almost all the vertebrate cells and acts as a sensory organelle to control tissue development and homeostasis maintenance. Numerous studies reveal that abnormalities in RPE lead to various retinal diseases, such as age\u2010related macular degeneration and diabetic macular oedema, but the mechanism of primary cilia in these physiological and pathological activities remains to be elucidated. Herein, we summarize the functions of primary cilia in the RPE development and the mutations of ciliary genes identified in RPE\u2010related diseases. By highlighting the significance of primary cilia in regulating the physiological and pathological processes of RPE, we aim to provide novel insights for the treatment of RPE\u2010related retinal diseases.<\/jats:p>","DOI":"10.1111\/jcmm.16882","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T09:25:59Z","timestamp":1630056359000},"page":"9084-9088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Primary cilia in retinal pigment epithelium development and diseases"],"prefix":"10.1111","volume":"25","author":[{"given":"Chunjiao","family":"Sun","sequence":"first","affiliation":[{"name":"College of Life Sciences Shandong Provincial Key Laboratory of Animal Resistance Biology Institute of Biomedical Sciences Shandong Normal University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Life Sciences Shandong Provincial Key Laboratory of Animal Resistance Biology Institute of Biomedical Sciences Shandong Normal University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8317-0018","authenticated-orcid":false,"given":"Xiaoqian","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Life Sciences Shandong Provincial Key Laboratory of Animal Resistance Biology Institute of Biomedical Sciences Shandong Normal University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-17121-0_74"},{"key":"e_1_2_10_3_1","first-page":"56997","article-title":"Primary cell cultures from the mouse 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