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There are many parallels between ADPKD and clear\u2010cell renal cell carcinoma (ccRCC); however, few studies have addressed the mechanisms linking them. In this study, we aimed to investigate their convergences and divergences based on bioinformatics and explore the potential of compounds commonly used in cancer research to be repurposed for ADPKD. We analysed gene expression datasets of ADPKD and ccRCC to identify the common and disease\u2010specific differentially expressed genes (DEGs). We then mapped them to the Connectivity Map database to identify small molecular compounds with therapeutic potential. A total of 117 significant DEGs were identified, and enrichment analyses results revealed that they are mainly enriched in arachidonic acid metabolism, p53 signalling pathway and metabolic pathways. In addition, 127 ccRCC\u2010specific up\u2010regulated genes were identified as related to the survival of patients with cancer. We focused on the compound NS398 as it targeted DEGs and found that it inhibited the proliferation of <jats:italic>Pkd1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> and 786\u20100 cells. Furthermore, its administration curbed cystogenesis in <jats:italic>Pkd2<\/jats:italic> zebrafish and early\u2010onset <jats:italic>Pkd1<\/jats:italic>\u2010deficient mouse models. In conclusion, NS398 is a potential therapeutic agent for ADPKD.<\/jats:p>","DOI":"10.1111\/jcmm.16903","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T16:50:04Z","timestamp":1632329404000},"page":"9597-9608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["NS398 as a potential drug for autosomal\u2010dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7499-6002","authenticated-orcid":false,"given":"Sixiu","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Nephrology Kidney Institute of People\u2019s Liberation Army (PLA) Changzheng Hospital Second Military Medical University Shanghai 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