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This study aimed to characterize the molecular features of OC based on the gene expression profile of 2752 previously characterized metabolism\u2010relevant genes and provide new strategies to improve the clinical status of patients with OC. Finally, three molecular subtypes (C1, C2 and C3) were identified. The C2 subtype displayed the worst prognosis, upregulated immune\u2010cell infiltration status and expression level of immune checkpoint genes, lower burden of copy number gains and losses and suboptimal response to targeted drug bevacizumab. The C1 subtype showed downregulated immune\u2010cell infiltration status and expression level of immune checkpoint genes, the lowest incidence of BRCA mutation and optimal response to targeted drug bevacizumab. The C3 subtype had an intermediate immune status, the highest incidence of BRCA mutation and a secondary optimal response to bevacizumab. Gene signatures of C1 and C2 subtypes with an opposite expression level were mainly enriched in proteolysis and immune\u2010related biological process. The C3 subtype was mainly enriched in the T cell\u2010related biological process. The prognostic and immune status of subtypes were validated in the Gene Expression Omnibus (GEO) dataset, which was predicted with a 45\u2010gene classifier. These findings might improve the understanding of the diversity and therapeutic strategies for OC.<\/jats:p>","DOI":"10.1111\/jcmm.16907","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T09:58:17Z","timestamp":1631699897000},"page":"9617-9626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Identification of metabolism\u2010associated molecular subtype in ovarian cancer"],"prefix":"10.1111","volume":"25","author":[{"given":"Xiaona","family":"Liu","sequence":"first","affiliation":[{"name":"Institutes of Biomedical Sciences Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoshen","family":"Wu","sequence":"additional","affiliation":[{"name":"Institutes of Biomedical Sciences Fudan University Shanghai 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