{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:19:49Z","timestamp":1792556389350,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Telocytes (TCs), a novel interstitial cell entity promoting tissue regeneration, have been described in various tissues. Their role in inter\u2010cellular signalling and tissue remodelling has been reported in almost all human tissues. This study hypothesizes that TC also contributes to tissue remodelling and regeneration of the human thoracic aorta (HTA). The understanding of tissue homeostasis and regenerative potential of the HTA is of high clinical interest as it plays a crucial role in pathogenesis from aortic dilatation to lethal dissection. Therefore, we obtained twenty\u2010five aortic specimens of heart donors during transplantation. The presence of TCs was detected in different layers of aortic tissue and characterized by immunofluorescence and transmission electron microscopy. Further, we cultivated and isolated TCs in highly differentiated form identified by positive staining for CD34 and c\u2010kit. Aortic\u2010derived TC was characterized by the expression of PDGFR\u2010\u03b1, PDGFR\u2010\u03b2, CD29\/integrin \u03b2\u20101 and \u03b1SMA and the stem cell markers Nanog and KLF\u20104. Moreover, TC exosomes were isolated and characterized for soluble angiogenic factors by Western blot. CD34\n                    <jats:sup>+<\/jats:sup>\n                    \/c\u2010kit\n                    <jats:sup>+<\/jats:sup>\n                    TCs shed exosomes containing the soluble factors VEGF\u2010A, KLF\u20104 and PDGF\u2010A. In summary, TC occurs in the aortic wall. Correspondingly, exosomes, derived from aortic TCs, contain vasculogenesis\u2010relevant proteins. Understanding the regulation of TC\u2010mediated aortic remodelling may be a crucial step towards designing strategies to promote aortic repair and prevent adverse remodelling.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.16919","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T08:46:54Z","timestamp":1632559614000},"page":"9697-9709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Telocytes in the human ascending aorta: Characterization and exosome\u2010related KLF\u20104\/VEGF\u2010A expression"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-8194","authenticated-orcid":false,"given":"Thomas","family":"Aschacher","sequence":"first","affiliation":[{"name":"Department of Cardio\u2010Vascular Surgery Clinic Floridsdorf and Karl Landsteiner Institute for Cardio\u2010Vascular Research Vienna 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