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However, the relationship between natriuretic peptide receptor C and inflammation of adipose tissue in atherosclerosis remains unknown. This study aims to explore the effect natriuretic peptide receptor C exerts on the regulation of the adipose inflammation in atherosclerotic mice induced by western\u2010type diet and its overlying mechanisms. To clarify the importance of NPRC of adipose inflammation in atherosclerotic mice, NPRC expression was measured in mice fed with chow diet and western\u2010type diet for 12\u00a0weeks and we found a considerable increase in adipose tissue of atherosclerotic mice. Global NPRC knockout in mice was bred onto ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> mice to generate NPRC<jats:sup>\u2212\/\u2212<\/jats:sup>ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> mice, which displayed remarked increase in browning of white adipose tissue and lipolysis of adipose tissue and decrease in adipose inflammation manifested by decreased macrophage invasion to form less CLS (crown\u2010like structure), reduced oxidative stress and alleviated expression of TNF\u03b1, IL\u20106, IL\u20101\u03b2 and MCP1, but increased expression of adiponectin in adipose tissue. Moreover, our study showed that white adipose tissue browning in NPRC<jats:sup>\u2212\/\u2212<\/jats:sup>ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> atherosclerotic mice was associated with decreased inflammatory response through cAMP\/PKA signalling activation. These results identify NPRC as a novel regulator for adipose inflammation in atherosclerotic mice by modulating white adipose tissue browning.<\/jats:p>","DOI":"10.1111\/jcmm.16931","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T05:41:50Z","timestamp":1631770910000},"page":"9837-9850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-6240","authenticated-orcid":false,"given":"Cheng","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Cardiology The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese National Health Commission and Chinese Academy of Medical Sciences The State and 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